p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage
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چکیده
منابع مشابه
Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration
Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of specific NF-κB subunits. Nfkb1-/- mice developed more severe gastric atrophy than wild-type (WT) mice 6 weeks after H. felis infection. In contrast...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2011
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2011.09.026